Molecular Mechanism of the Toxicity

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Mycotoxins are secondary metabolites produced by many microfungi, including Alternaria, Aspergillus, Claviceps, Fusarium, Penicillium, etc. The contamination of mycotoxins to cereals and feedstuffs are inevitable, especially in wet weather, which causes enormous economic lost to food and feed industry every year worldwide. Mycotoxins can exert acute, sub-acute and chronic toxicological effects to animals and humans. On the cellular level, mycotoxins and their metabolites can elicit different kinds of disorders and adverse effects, such as oxidative stress, ribotoxic stress, DNA damage and apoptosis. Some enzymes and bacteria are implicated in the biotransformation of mycotoxins. However, the molecular mechanism of the toxicity and metabolism of many mycotoxins are unclear.

 

A sustainable food system is insecure if toxins are a threat. There are three types of natural non-proteinaceous toxins that compromise reliability of food systems: cyanotoxins for freshwater aquatic products, phycotoxins for seafood, and mycotoxins mainly for cereals (also for other plant-based foods and food-products of animal origin).

This Research Topic aims to focus on several knowledge gaps that require in-depth research, with an emphasis on new or emerging toxins recently appearing due to global warming and international trade. In this context, several important issues related to toxins stand out for which new information and scientific evidence should be provided. These issues include: monitoring and analytical challenges (including the requirement for certified reference materials), the need for better understanding of toxin mode of action and toxicology, as well as the need to improve risk assessment, and the development of novel mitigation strategies.

We invite scientists from these relevant fields to contribute to this exciting area of research that combines pharmacology, analytical chemistry, toxicology, mycology, phycology, and food safety.

In order to reduce delays, authors should adhere to the level, length and format of the Longdom Publishing Journals at every stage of processing right from manuscript submission to each revision stage. Submitted articles should have a 300 words summary/abstract, separate from the main text. The summary should provide a brief account of the work by clearly stating the purpose of the study and the methodology adopted, highlighting major findings briefly. The text may contain a few short subheadings of no more than 40 characters each.

Media contact:

Larry Tyler

Managing Editor

Journal of Clinical Toxicology

Whatsapp: +1-504-608-2390

Mail ID: [email protected]