New Immunoassays of Bioactive TSH Improve Detection of Thyroid Disorders

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Journal of Thyroid Disorders & Therapy offers the most comprehensive and reliable information pertaining to the latest developments in the field. The Journal also believes in advancing new hypotheses and opinions by means of its high quality Reviews, Perspectives, and Commentaries. Thus, the content published in the journal is original and comprehensive.

Hypothyroidism also called Underactive Thyroid is a very common deficiency of the thyroid in which the endocrine gland does not produce sufficient amount of thyroid hormones (T3 and T4). Diagnosing hypothyroidism early enough should provide rapid access to treatment and have a positive impact on the daily life of the population. Since the concentration of TSH may increase by a factor of 100 when the concentration of FT4 is only reduced by a factor 2, TSH is a much more informative than FT4 and is defined as the first-line marker of thyroid deficiency. When TSH level is beyond the upper limit of the reference range, hypothyroidism may be envisaged. Assessment of FT4 level will then determine the biological significance of this dysfunction. Therapy with levothyroxine will be usually considered for patients with a persistent serum TSH level of more than 8 mIU/L.

TSH assays have long been showing discordances, especially in the upper limit of the reference range. There is thus a need to improve TSH measurement and detection of thyroid dysfunction. This study aimed at evaluating the ability of new TSH assays to detect early thyroid deficiency in a healthy population with no suspicion of thyroid disorders.

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Regards
Denise Williams
Editorial Manager     
Journal of Thyroid Disorders & Therapy
E-mail id: [email protected]