Skin Inflammatory Disorders T cell

The skin is comprised of structural, innate and adaptive immune cells. Defects in any of the three arms disrupts skin homeostasis leading to impaired host defence responses and/or skin inflammatory disorders. Skin inflammatory disorders are a group of heterogenous diseases comprised of immunodeficiencies and autoimmune disorders (Psoriasis, Vitiligo, Alopecia areata, Scleroderma) and immune hyperreactivity (atopic dermatitis, allergic contact dermatitis, prurigo nodularis). For many of these diseases, it is well accepted that dysregulated T cell responses drive disease pathogenesis. Given the heterogeneity of T cells as well as the lack of disease specific model systems, what remains unclear is the impact of these T cell subsets as well as their relative contribution to skin inflammation. As mentioned, T cells are a heterogenous group of cells that include conventional T cells, innate-like T cells (NKT and MAIT cells) and  T cells. Conventional T cells, based on differentiation status, are divided into naïve, effector and memory T cells. The latter can be further segregated into central memory (TCM), peripheral memory (TPM) and tissue resident memory (TRM) T cell types, based on their location and migratory patterns. While different studies have elucidated the development, localization and function of different T cell subsets in the context of infectious diseases, there is still a limited understanding of the relative roles of these T cell subsets in the context of inflammatory disorders. This is particularly evident in the context of skin inflammatory diseases, where, due to both a paucity of disease relevant model systems as well as inability to specifically target subsets of T cells, the contribution of different T cell populations to the disease pathology is still unclear.

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