Xenobiotic Exposure and Predictive Toxicology
Background: An emerging paradigm in predictive toxicology is focused on the interaction among xenobiotics, the host and the microbiome. The outcome of this interaction is an important regulator of many diseases. The microbiome consists of the indigenous microbial communities and the host environment that they inhabit. The microbiome includes microbes that are both helpful and potentially harmful, and in a healthy individual, these microbial communities coexist without problems. However, when this balance is disturbed due to the exposure of xenobiotics, dysbyosis can occur. One such factor that is emerging as a regulator of this balance is exposure to environmental pollutants that may perturb host-microbiome interactions to promote disease.
Goal: The significance of the microbiome is a rapidly emerging field of study, and toxicologists and pharmacologists recognize the importance of studying the impact of xenobiotics and pharmaceuticals on gut microbiome dysbiosis and immune responses. It is also known to play a role in the development of immune response. However, addressing the knowledge-gaps in this immense area can seem intimidating, especially in the context of animal models that are used to define these interactions and outcomes, as well as, outlining studies to assess multi-generational and developmental immunotoxicity. This research topic is designed to provide updated information - from a historical perspective to study design and analysis, as well as potential therapeutic implications - by experts in the field.
Scope: The areas covered by this Research Topic will provide information that will be utilized by a broader scientific community, going beyond the scope of toxicologists and pharmacologists to incorporate the broad study of microbiome and gut-associated immune responses into risk assessment and/or therapeutics.
Details for Authors: This Research Topic envisages several sections, that would span from the historical perspective of microbiome, to some of the current advances in microbiome research as it pertains to predictive toxicology. More specifically, topics will include:
• an overview of experimental models with an emphasis on the prediction of toxicology due to exposure to xenobiotics
• how the exposure to xenobiotics changes the microbial population and immune status of animals at different stages and states:
o adult stage
o susceptible stage
o Gender disparity
• microbiome experimental designs for more effective planning and execution of multi-generational toxicology studies
• case study through the steps of the design, data collection, and reporting process
• limitations and advantages of current microbiome analysis tools in predicting toxicology of xenobiotics
• emerging issue of microbiome therapeutics with a focus on the regulatory aspects of microbiome.
Journal of Clinical Toxicology
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