Study links gene to inherited form of autism

Image Inherited mutations in a gene called ACTL6B lead to autism, epilepsy and intellectual disability, according to a new study1. The mutations are recessive, which means that they lead to autism only if a person inherits them in both copies of the gene — one from each parent, who are silent carriers. Most other mutations implicated in autism are spontaneous, or ‘de novo,’ mutations, which are not inherited. The study suggests that recessive mutations in ... Read More

Biomarkers, Cytokines, and Chemokine’s

Image Biomarkers, Cytokines, and Chemokine’s Understanding the microenvironment within skin cancers is key for the development of new preventative and therapeutic treatment options. Research advances in skin cancers such as melanoma have revolutionized immunotherapeutic treatment options, for example through the provision of checkpoint inhibitor trials that have benefitted not just melanoma patients, but also patients with a wide array of other cancers, including less readily accessible cancer types. However, checkpoint inhibitor success is limited in melanoma and... Read More

Skin Inflammatory Disorders in T cell

Image Skin Inflammatory Disorders T cell The skin is comprised of structural, innate and adaptive immune cells. Defects in any of the three arms disrupts skin homeostasis leading to impaired host defence responses and/or skin inflammatory disorders. Skin inflammatory disorders are a group of heterogenous diseases comprised of immunodeficiencies and autoimmune disorders (Psoriasis, Vitiligo, Alopecia areata, Scleroderma) and immune hyperreactivity (atopic dermatitis, allergic contact dermatitis, prurigo nodularis). For many of these diseases, it is well accepted that dys... Read More

Psychopathology Research

Image Psychopathology Research Psychopathology needs to be viewed as a set of theoretical constructs which can be altered over time and they thus require periodic calibration. Furthermore, the way in which we describe the mental symptoms must be adapted to the scientific needs of the age in which we live related, for instance, with the detail of the data obtained by the auxiliary means of diagnosis and which are different from those observed in the 19th century. Jaspers had already said with regard to the evolution of psychopathology: «general psych... Read More

The danger of blaming Covid-19 deaths on our genes

Image A profound and unexpected disparity in Covid-19 death rates has emerged among different countries. In South Korea, Norway and Australia, for example, less than 3% of confirmed cases die, while in Belgium, Italy and the United Kingdom, the case fatality rate is as high as 14%. Might the same gene be related to both clinical conditions? The researchers' findings support the idea that there is some correlation, although the study -- which found only 37 patients with the APOE4 ... Read More

Two Genetic Regions Linked with Severe COVID-19

Image It’s not yet clear why some people infected with SARS-CoV-2, the virus that causes COVID-19, get really sick, while others have only mild symptoms. There’s some evidence that chronic health conditions—such as hypertension and diabetes can play a role, and scientists know that people’s genes can influence how their bodies react to other viruses. In a preprint posted to medRxiv on June 2, researchers describe a genome-wide association study (GWAS) of samples from 1,... Read More

Fungal Pathogens

Image Fungal Pathogens Surface components in fungal cells include cell wall molecules and, in certain cases, capsular structures. In pathogens, these components are responsible for key events during interaction with the host. These events include recognition of pathogens by the immune system and generation of damage to host cells and tissues. The molecular nature of surface structures in fungi is vast and may include (glyco)proteins, polysaccharides, lipids and pigments. Many of them have been strictly associated with the antifungal immune response, as well as with step... Read More

Trichoderma species Cellulases Produced by Solid State Fermentation

Image Trichoderma species Cellulases Produced by Solid State Fermentation   The main aim of this study was to analyze eight species of Trichoderma for cellulase enzyme production by solid state fermentation. Different carbon sources such as wheat bran, corn cob, sucrose, maltose and filter paper were used. Highest celluase enzyme production was achieved with T. harzianum on media supplemented with corn cob. The optimum pH, temperature and thermal stability of isolated enzymes were also analyzed. The best pH for enzyme production was found between 4-6. The... Read More

Coding region

Image The coding region of a gene, also known as the CDS (from coding sequence), is the portion of a gene's DNA or RNA that codes for protein.Studying the length, composition, regulation, splicing, structures, and functions of coding regions compared to non-coding regions over different species and time periods can provide a significant amount of important information regarding gene organization and evolution of prokaryotes and eukaryotes.This can further assist in mapping the human genome... Read More

Genotype

Image The genotype is the part of the genetic makeup of a cell, and therefore of any individual, which determines one of its characteristics (phenotype). The term was coined by the Danish botanist, plant physiologist and geneticist Wilhelm Johannsen in 1903. The genotype is one of three factors that determine phenotype, along with inherited epigenetic factors and non-inherited environmental factors. Not all organisms with the same genotype look or act the same way because appearance ... Read More

Quick Reliable Exploration of the PDB Universe Seeks a New Template

Image Quick Reliable Exploration of the PDB Universe Seeks a New Template Near-native protein structure prediction through Template Based Modelling (TBM) has been a major realistic goal of structural biology for several years. The TBM algorithms require the best-set of templates for a target protein sequence to maximally cover it and construct its correct topology. However, the accuracy of such prediction algorithms suffers from the algorithmic and logical problems of our template search measures which fail to quickly screen reliable structures for a target sequence. In... Read More

Gene expression profiling

Image In the field of molecular biology, gene expression profiling is the measurement of the activity (the expression) of thousands of genes at once, to create a global picture of cellular function. These profiles can, for example, distinguish between cells that are actively dividing, or show how the cells react to a particular treatment. Many experiments of this sort measure an entire genome simultaneously, that is, every gene present in a particular cell. Several transcriptomics technologies can be used to generate the necessary data to analyse. DNA microarrays measure the relative ac... Read More

Single-cell transcriptomic analysis of Alzheimer’s disease

Image TranscriptLongdom Publishing is a total set of transcripts in a given organism and referred to as an expression profiling that examines the expression level of mRNAs in a given cell population. TranscriptLongdom Publishing includes high-throughput techniques based on DNA microarray. TranscriptLongdom Publishing:Open Access Journal is at higher echelons that enhance the intelligence and information dissemination on topics closely related to TranscriptLongdom Publishing. They provide a uni... Read More

Visualization of High Throughput Genomic Data Using R and Bioconductor

Image Visualization of High Throughput Genomic Data Using R and Bioconductor DNA microarrays, technology aims at the measurement of mRNA levels in particular cells or tissues for many genes simultaneously. Microarray in molecular biology results in huge datasets that need rigorous computational analysis to extract biological information that lead to some conclusion. From printing of microarray chip to... Read More

Neurological Disorders | Pathology

Image Neurological Disorders | Pathology Tauopathies are characterized by the aberrant modification, splicing, and aggregation of the microtubule-associated protein Tau into filamentous inclusions in neurons and glia. Tau pathology is present across a wide spectrum of neurodegenerative diseases including Alzheimer's disease, fronto-temporal dementias, Pick's disease, progressive supranuclear palsy, chronic traumatic encephalopathy, Huntington's and Parkinson's diseases, among others. Given the combined prevalence of these diseases and the importance of T... Read More

Chronic Kidney Disease

Image Chronic Kidney Disease The prevalence of both chronic kidney disease (CKD) and metabolic bone diseases increases with age. Given the aging of the population as a prevailing demographic trend in the Western world, these medical conditions represent a significant challenge. Moreover, CKD in its advanced stages (from CKD grade 3) is associated with changes of calcium-phosphate metabolism, which, together with the lack of active di-hydroxylated vitamin D, constitute mineral and bone disease that is connected with CKD (CKD-MBD). The bone component of CKD-MBD (re... Read More

Brain Pathology

Image Brain Pathology The Transient Receptor Potential (TRP) channels compromise a superfamily of polymodal receptors that are critically involved in the detection of diverse stimuli such as temperature or pH changes, noxious chemicals or mechanical forces. This ability to sense environmental changes is essential for survival, and thus the disruption of TRP channel function can have a severe impact on human health, as evidenced by the increasing number of hereditary and acquired diseases linked to TRP channels. Many members of the TRP channel superfamily are expressed i... Read More

Genetic Testing

Image Genetic testing is a diagnostic method that helps confirm the presence or absence of genetic disorders by looking for changes or mutations in fundamental units of hereditary material called genes. Mutations can be inherited from either one or both parents or appear spontaneously and usually affect the normal functioning of a gene leading to various symptoms. Genetic testing can be useful to identify genetic diseases in a fetus, to find out whether parents have a risk of pa... Read More

Latest innovation in synthetic biology

Image Current Synthetic and Systems Biology is an open access journal publishing original peer-reviewed research articles in experimental and theoretical aspects of the function of biological systems at the molecular, cellular or organismal level, in particular those addressing the engineering of biological systems, network modelling, quantitative analyses, integration of different levels of information and synthetic biology Current Synthetic and Systems Biology is a peer reviewed scientific journal known for rapid dissemination of high-quality research. This Current Synt... Read More

Emerging trends in systems biology

Image Current Synthetic and Systems Biology research objective is to encourage and assist the development of better and faster measures of systems-biology. In cases where we believe we can contribute directly, as opposed to through highlighting the work of others, we are producing our own measures of research activity. Our work is mainly of interest to investors, organizations and individuals in the financial sector and to significant corporations with global operations, as well as governments and academic researchers. Current Synthetic and Systems Biology play a key role in the knowled... Read More

Biotechnologies in wild felids

Image Conservation strategies in natural habitats as well as in breeding centers are necessary for maintaining and reinforcing viable populations of wild felids. Among the fundamental knowledge that is required for conservation breeding, a solid understanding of reproductive biology is critical for improving natural breeding and enhance genetic diversity. Additionally, it offers the opportunity to develop assisted reproductive technologies (ARTs) in threatened and endan... Read More

Gene Synthesis

Image                                                 Gene Synthesis Current Synthetic and Systems Biology is aimed at everyone working in the modelling and discovery of emergent properties in complex biological systems. Also, it seeks scientists relating the structure and dynamics of living organisms with their physiology and phenotypic traits for the understanding of the whole. In addition to the highest-quality original articl... Read More

SYNTHETIC BIOLOGY

Image                                              SYNTHETIC BIOLOGY Current Synthetic and Systems Biology is an journal that provides an opportunity to researchers and scientist to explore the advanced and latest research developments in the field of synthetic and system biology and related academic disciplines. The Editors select manuscripts based on their novelty and wide biological significance. Although the primary emphasis of the journal is ... Read More

The Genomic Route To Targeted Cures

Image The scientists discovered close to 200,000 DNA markers in Asians, which had been previously unreported in existing genetic databases. The catalogues that are now used for disease-association studies in Asia, including India, are those that have primarily been generated in western populations, hence of limited use in Asia.” The scientists also found 23 per cent of previously unreported protein variants. “Since alterations of proteins are usually associated with disease, we specifically investigated those ... Read More

A proteomics landscape of circadian clock in mouse liver

Image The mammalian circadian clock includes a “master clock” within the suprachiasmatic nucleus (SCN) of hypothalamus and “peripheral clocks” within other tissues of the body. The “master clock” functions as an “orchestra conductor” to direct “peripheral clocks” through yet-to-be defined pathways, allowing animals to adapt their feeding, activity, and metabolism to predictable daily changes in the environment. Circadian clocks orchestrate physiological rhythms via the temporal regulation of gene expression to control core cloc... Read More

Combining biological research and engineering

Image                                       Combining biological research and engineering On behalf of the Journal, as Editor-in-Chief, it is my distinct honor and privilege to welcome you to the Current Synthetic and Systems Biology The journal aims to spread knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Modern Scientific Techniques. The open access journal is published by L... Read More

Current Synthetic and Systems Biology

Image                                                Current Synthetic and Systems Biology The Current Synthetic and Systems Biology aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to like molecular biology, theoretical biology, structural biology, marine biology etc.. The Journal emphasizes high-level research and education. Original research articles, revi... Read More

Major Considerations and Outcomes of Clinical Studies on Vitamin D Deficiency in Patients with Crohn's

Image Major Considerations and Outcomes of Clinical Studies on Vitamin D Deficiency in Patients with Crohn's Introduction: The literature shows a bimodal incidence of Crohn's disease in relation to age, with peaks from 15-40 and from 50-80 years and more women have Crohn's disease than men. Clinical studies have shown a direct correlation of vitamin D deficiency with Crohn's disease. Objective: Using a systematic review, the objective of this study was to identify the main correlations and outcomes of clin... Read More

Bioinformatics

Image Bioinformatics Bioinformatics can be defined as “the application of computational tools to organize, analyze, understand, visualize and store information associated with biological macromolecules”. Bioinformatics is an interdisciplinary scientific field of life sciences. Bioinformatics research and application include the analysis of molecular sequence and genomics data; genome annotation, gene/protein prediction, and expression profiling; molecular folding, modeling, and design; building biological networks; development of d... Read More

QUANTUM COMPUTING: THE FUTURE

Image On behalf of the Journal, as Editor-in-Chief, it is my distinct honour and privilege to welcome you to the Journal of Theoretical and Computational Science. The Journal of Theoretical and Computational Science aims to spread knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Modern Scientific Techniques. The open access journal is published by Longdom Publishing who hosts open ac... Read More

Clinical-Therapeutic Importance of Bioimpedance in Patients with Lymphedema

Image Clinical-Therapeutic Importance of Bioimpedance in Patients with Lymphedema Introduction: Lymphedema is characterized by abnormal accumulation of macromolecules and soft tissue fluids. Bioimpedance is a method that measures intra- and extracellular volumes by body segment, and has been currently used in lymphedema. Objective: The objective of this study was to conduct a systematic review of the clinical-therapeutic importance of bioimpedance in patients with lymphedema. Methodology: The present... Read More

Genomic Strategies for Global Health

Image Tumor Genomics Tumor Genomics is the investigation of hereditary transformations in charge of malignancy, utilizing genome sequencing and bioinformatics. Disease genomics is to enhance growth treatment and results lies in figuring out which sets of qualities and quality associations influence diverse subsets of tumors. Universal Cancer Genome Consortium (ICGC) is a deliberate experimental association that gives a discussion to joint effort among the world'... Read More

Theoretical and Computational Science: A Better Way to Modern Science

Image On behalf of the Journal, as Editor-in-Chief, it is my distinct honour and privilege to welcome you to the Journal of Theoretical and Computational Science. The Journal of Theoretical and Computational Science aims to spread knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Modern Scientific Techniques. The open access journal is published by Longdom Publishing who hosts open ac... Read More

Synthetic Biology

Image On behalf of the Journal of Current Synthetic and Systems Biology, as Editor-in-Chief, it's far my awesome honour and privilege to tell you that, it's far been five lengthy years we've commenced the Journal, now we are celebrating the Fifth Anniversary and we are privileged to welcome Innovative Society to our magazine. As Editor-In-Chief it is my brilliant delight and honour to welcome you to the Journal of Current Synthetic and Systems Biology. ... Read More

Theoretical and Computational Science

Image On behalf of the Journal, as Editor-in-Chief, it is my great pleasure and honour to welcome you to the Journal of Theoretical and Computational Science. The Journal of Theoretical and Computational Science aims to share wisdom and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Computational Science. The open access journal is lead by our eminent ... Read More