Metastatic Pancreatic Exocrine Cancer
Metastatic Pancreatic Exocrine Cancer
PEC is a frequent cancer both in women and men representing in United States about the 3.1% of all cancer diagnosed. Curability rate are very low even when disease is at an early resectable stage with a 5-years overall survival. The 5-year survival rate for people with stage IA pancreatic cancer is about 14%. For stage IB cancer, the 5-yearsurvival rate is about 12%. For stage IIA pancreatic cancer, the 5-yearsurvival rate is about 7%. For stage IIB cancer, the 5-year survival rateis about 5%. The 5-year survival rate for stag... Read More
In adult mammals, peripheral nervous system (PNS) neurons regenerate relatively efficiently, whereas central nervous system (CNS) neurons cannot regenerate. The difference in regenerative capacity between CNS and PNS neurons has been attributed to extrinsic signals, and to intrinsic growth ability and the inhibitory glial environment. PNS neurons possess the fundamental and conserved ability to regenerate their axons following injury, in a process mainly controlled by the PNS glial cells surrounding neurons and Schwann cells (SCs). Several studies have reported the regenerative ability of S... 
Prosthodontics- Dental Care
Considering this phenomenon 
Orthodontics-Dental Research
Considering this phenomenon 
Natural killer (NK) cells are innate lymphoid cells that have a significant role in regulating the defenses against cancer development and certain viral infections. They are equipped with an array of activating and inhibitory receptors that stimulate or diminish NK cell activity, respectively. Inhibitory receptors include, among others, the MHC class I ligands killer cell immunoglobulin-like receptors (KIR) in humans, and members of the Ly49 family of receptors in mice, and CD94/NKG2A. Activating receptors include cytokine and chemokine receptors, and those that interact with ligands expres... 
Cancer immunotherapy has recently emerged as the fourth treatment modality, in addition to surgery, chemotherapy and radiotherapy. These advances are the result of important discoveries in the field of regulation of the immune response, especially on the mechanisms which turn "on" and "off" immune responses. A disease which has proved to be a canonical model to test therapeutic immunotherapy approaches is the immunogenic cutaneous melanoma. So far, "passive" immunotherapy with monoclonal antibodies has outpaced "active" immunotherapy with antitumor va... 
Inositol phosphates and phosphoinositides are integral to a number of critical intracellular signaling pathways in epithelia, endothelia and immune cells that are fundamental to GI health and can contribute to GI pathology when disrupted. These pathways broadly pervade almost every aspect of GI function including, secretion, absorption, innate and adaptive immunities, and are present in all cell types. Examples include excessive or insufficient fluid secretion through disregulation of ion channel function that can lead to diarrhea, constipation, or abnormal secretion of bile or pancreatic e... 
Forensic Pathology encompasses all aspects of forensics, including pathology, science, toxicology, human identification, mass disasters/war graves, nursing, police surgeons/scene of crime, entomology, biology, and DNA. Balanced to reflect modern advances in the subjects through peer-reviewed papers, short communications and meeting proceedings, and case reports, Forensic Science, Medicine and Pathology provides coverage on the full international spectrum of forensic science, neither concentrating on the sole practice of a single country or becoming top heavy with a pa... 
Diabetes in pregnancy, including gestational diabetes (GDM) and pre-existing diabetes, imposes significant and adverse influences on maternal health as well as fetal development and child health. In the mother, GDM usually resolves after pregnancy unless it represents previously undiagnosed type 2 diabetes which is first recognized during pregnancy. GDM is linked to substantially increased risk for developing type 2 diabetes and cardiovascular disorders. Despite the fact that GDM has been acknowledged as a subtype of diabetes for decades, appropriate cutoff points and procedures for screeni... 
Journal of Forensic Pathology is an multidisciplinary journal that publishes original work with regard to various scientific disciplines pertaining to forensic sciences. The journal focuses on the current advancements in the field of forensic science and criminology and provides reliable information regarding the developments in forensic science.
This part of journals is delighted to accept Research Papers, Review Articles, Short Communications, Case Reports, Mini- Reviews, Opinions, Letter to Editors Etc., focused on Forensic science and Crime Investigation.
The journal... 
Journal of Clinical & Experimental Cardiology is one of the best open access journals that aims to publish the most complete and reliable source of information on discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc. in this field and provide online access without any restrictions or subscriptions to researchers worldwide.
The scientists, doctors, professors, researchers can submit their high quality papers to enhance their research work through online platform of our Journal.
Cur... 
Cardiovascular disease is sometimes called “heart disease”, but in medical terms, they are not exactly the same thing. Heart disease is a general term for conditions affecting the structure of the heart and the way it functions. All heart diseases are cardiovascular diseases. However, not all cardiovascular diseases are heart diseases. An example is stroke, which affects blood vessels in the brain, but not the heart itself.
Risk factors for cardiovascular disease are particular habits, behaviors, circumstances or conditions that increase a per... 
Skin is the largest organ of the body and is necessary for survival, since it performs many functions such as providing a physical barrier to the external environment, sensation, retention of normal hydration and thermal regulation. Significant skin loss is associated with high mortality and morbidity in the acute phase, and with physically and cosmetically drastic scarring in the long term. There are a number of tissue-engineered products in the clinic that are used as skin substitutes to promote healing of traumatic burn and diabetic wounds, producing results that satisfy the barrier func... 
Alopecia Areata (AA) is a CD8+ T cell-mediated autoimmune disease that is directed against anagen-associated autoantigens which become exposed to the immune system following the collapse of the hair follicle’s physiological immune privilege, and presumably only when hair follicles undergo active growth, produce a hair shaft, and are engaged in pigment synthesis (anagen).
The mechanisms that contribute to the development of AA are currently under investigation. A major genome wide association study (GWAS) strongly supported the importance of NKG2D in AA, which had previo... 
There is a connection between obesity, diabetes and cancer that is well-accepted by the medical and scientific communities. Epidemiological evidence suggests that people with diabetes are at significantly higher risk for many forms of cancer. Type 2 diabetes and cancer share many risk factors, but detailed molecular/ mechanistic links between the two diseases are incompletely understood.
Moreover, some medications used to treat cancer are associated with hyperglycemia and diabetes, and a reverse pattern is also noted - that some medications used to ameliorate hyperglycemia and diabet... 
This Research Topic focuses on recent advances in understanding the neuronal dysfunction of diabetic brain. Insulin signaling plays a significant role in synaptic function in the brain. Cognitive dysfunction and decrease in the brain size have been observed in patients with diabetes. Insulin resistance is associated with reductions in cerebral glucose metabolism even in prediabetic individuals. These observations are generally associated with Alzheimer’s disease (AD). Several epidemiological studies have indeed identified diabetes as a risk factor for AD. The threshold of amyloid burd... 
EBOLA Virus Infection
Ebola is deadly disease caused by virus. There are five strains, and four of them can make people sick. After entering the body, it kills cells, making some of them explode. It wrecks the immune system , causes heavy bleeding inside the body, and damages almost every organ.
The virus is scary, but it’s also rare. You can get only from direct contact with an infected person’s body fluids.
It spreads to people by contact with the skin or bodily fluids of an infected animal, like a monkey, chimp, or fruit bat. Then it moves from p... 
Type 1 diabetes is a challenging condition to manage since it includes many facets such as treatment with insulin, technical devices, physiological and behavioral factors. Regular exercise is a cornerstone in diabetes treatment, but management of different forms of physical activity could be difficult for both the individual with type 1 diabetes as well as the health-care provider.
People with type 1 diabetes tend to be as physically inactive as the general population, where we see a large percentage of individuals not maintaining a healthy body composition nor achieving the minimum ... 
Type 2 diabetes (T2D) is one of the most prevalent chronic diseases, affecting about 415 million people worldwide in 2015. The etiology of T2D involves an interaction between genetic predisposition and lifestyle (e.g. overweight, unhealthy diet, sedentariness).
The past decade has seen fast-paced, ...
Type 2 diabetes (T2D) is one of the most prevalent chronic diseases, affecting about 415 million people worldwide in 2015. The etiology of T2D involves an interaction between genetic predisposition and lifestyle (e.g. overweight, unhealthy diet, sedentariness).
The past de... 
Nicotinic acetylcholine receptors (nAChRs) are ion-gated channels that have diverse function in nervous and non-nervous tissues. The α9 and α10 subunits are members of the subfamily I, epithelial ion-gated nicotinic receptor gene family. These subunits are the most recently discovered (and perhaps the last to be discovered) nAChR subunits in mammals, but are phylogenetically the oldest.
The α9 and α10 subunits are not expressed in the mammalian brain, making them unique among nAChRs. They were first localized in cochlear hair cells. As a consequence of their d... 
The complexity of the immune system at the gene, protein, cell and organism level continues to provide a major challenge. Genomic landscape analysis, single-cell analysis and mass data acquisition encompassing genomics, transcriptomics, metabolomics and proteomics have now added new levels of complexity. With the rapid progress in these and other fields of immunology, it has become more important than ever to agree on a nomenclature, i.e. to agree on a consensus for naming novel genes, proteins, cells and biological reagents related to the immune system. Names that were given initially may,... 
Infectious Diseases
Infectious diseases are caused by pathogenic microorganisms, such as bacteria, viruses, parasites or fungi; the diseases can be spread, directly or indirectly, from one person to another. Zoonotic diseases are infectious diseases of animals that can cause disease when transmitted to humans.
Germs, or microbes, are found everywhere - in the air, soil, and water. There are also germs on your skin and in your body. Many of them are harmless, and some can even be helpful. But some of them can make you sick. Infectious diseases are disease... 
Coronavirus
Coronaviruses (CoV) are a large family of viruses that cause illness ranging from the common cold to more severe diseases such as Middle East Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome (SARS-CoV). A novel coronavirus (nCoV) is a new strain that has not been previously identified in humans.
Coronaviruses are zoonotic, meaning they are transmitted between animals and people. Detailed investigations found that SARS-CoV was transmitted from civet cats to humans and MERS-CoV from dromedary cam... 
“Vaccination and Immune Disorders” mainly focuses on the gathering and concentrate on the understanding risks activity on 
The goal of public health is to prevent disease. It's much easier and more cost-effective to prevent a disease than to treat it. That's exactly what immunizations aim to do. Immunizations, or vaccines as they're also known, safely and effectively use a small amount of a weakened or killed virus or bacteria or bits of lab-made protein that imitate the virus in order to prevent infection by that same virus or bacteria.
Pathology and Immunology:
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Infection with hepatitis B virus (HBV) can be prevented by vaccination with HB surface antigen, which induces HBS specific antibodies and T cells. But the immunization status of workers and its relationship with occupational factors are not well documented. The goal is to examine the factors of risk and the immunization status against HBV among a population of workers. An assessment of the vaccination and the immunization status against HBV was conducted among a miscellaneous population of French workers, recruited from a medical occupational center, during a cross-sectional study. A repres... 
Teratogen:
A teratogen is an agent that can disturb the development of the embryo or foetus
Teratogenicity:
It refers to the capacity of a drug to cause foetal abnormalities when administered to the pregnant mother.
Drugs can affect the foetus at 3 stages:
Fertilization and implantation: conception to 17 days—failure of pregnancy which often goes unnoticed.
Organogenesis: 18 to 55 days of gestation, most vulnerable period, deformities are p... 
Dermatology centers around the analysis and treatment of conditions identified with skin, hair and nails. It additionally focuses on keeping up the wellbeing of your skin. Your skin is your body's biggest organ, which covers and secures your body. Anything that aggravates stops up or arouses your skin can cause side effects, for example, redness, growing, consuming and tingling.
As of now in time, the whole world is experiencing skin related ailments like psoriasis, skin inflammation, dermatitis, rashes, skin inflammation, dandruff, skin contaminations, skin consumes, rosacea,... 
Lyme Disease
Lyme disease is the most common vector-borne disease in the United States. Lyme disease is caused by the bacterium Borrelia burgdorferi and rarely, Borrelia mayonii. It is transmitted to humans through the bite of infected blacklegged ticks. Typical symptoms include fever, headache, fatigue, and a characteristic skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system. Lyme disease is diagnosed based on symptoms, physical findings (e.g., rash), and the possibility of exposure to infected ticks. Labor... 
Tuberculosis
Tuberculosis -- or TB, as it’s commonly called- is a contagious infection that usually attacks your lungs. It can spread to other parts of your body, like your brain and spine. A type of bacteria called Mycobacterium tuberculosis causes it.
There are two forms of the disease:
Latent TB: You have the germs in your body, but your immune system stops them from spreading. That means you don’t have any symptoms and you’re not contagious. But the infection is still alive in your body and can one day become acti... 
In 2014 the Advisory Committee on Immunization Practices (ACIP) approved a dose of 13-valent pneumococcal conjugate vaccine (PCV13) for all adults at age 65 years. This further complicated the pneumococcal vaccination schedule, which was already one of the most complicated schedules. This study documents simplified schedules that were considered and discarded by the pneumococcal working group before making the most recent recommendation. We examined the marginal cost-effectiveness of several simplified schedules for older adults (age 50+ years) when compared with current recommendations. Ou... 
The capacity of bacteria to resist against the ejects of an antibiotic is called antibiotic resistance. Antibiotic resistance is due to the change in bacteria by some approach that eliminates or reduces the efficiency of chemicals, drugs, or other agents designed for treatment against infections. The survival and continuously multiplication of bacteria causes more destruction in human body. A few years back, main focus of research was centered regarding gram-positive bacteria resistant. Currently, clinical microbiologists strongly are in view that multidrug-resistant gram-negative bacteria ... 
New approach to pain treatment in diseases of the pancreas
One of the worst symptoms associated with inflammation or cancer of the pancreas is severe chronic pain. Pancreatic pain is difficult to treat, because many painkillers prove ineffective in pancreatic patients. In a recent study, a team at the Technical University of Munich (TUM) discovered the cause of this phenomenon for the first time: a particular neuroenzyme in the body is present in the nerves of the organ in high concentrations.
In many cases only potent analgesics such as opiates are able... 
The pancreas is a large gland in the abdomen. It secretes pancreatic juices into the small intestine to digest food, and secretes insulin into the bloodstream to regulate glucose levels. The pancreas is both an endocrine gland (releasing juices directly into the bloodstream) and an exocrine gland (releasing juices into ducts).
Microbiota in pancreatic health and disease: the next frontier in microbiome research
Diseases intrinsic to the pancreas such as pancreatitis, pancreatic cancer and type 1... 
A number of different approaches aimed at broadening the cross-protective ability of seasonal influenza vaccines are being explored today. Priming a seasonal vaccine with three administrations of DNA encoding H1 HA corresponding to the HA in the seasonal vaccine has been shown to confer protection against heterologous H1N1 influenza. Here we evaluated the heterosubtypic protection induced by a seasonal influenza vaccine when primed with H1 HA DNA and, in parallel, when given as a homologous prime/boost regimen. Balb/c mice were immunized three times with vaccine homologous H1 HA DNA prior t... 
Neospora caninum, the parasite that causes neosporosis, is known worldwide as one of the main drivers of abortion in cattle herds, causing economic losses when raising livestock. Parasitic infection and transmission among animals are difficult to combat, and both diagnostics and controls must be applied to reduce the spread of the pathogen. For control, herd vaccinations represent an alternative, but the current lack of a safe and effective vaccine prevents this method. The parasite has a significant array of structural proteins that assist in the process of infection; surface antigens (SAG... 
Journal of Vaccines & Vaccination is on the leading open-access journal making awareness to the people on vaccination through our articles. We have been 
Accumulating evidence shows that tumours contain a distinct subpopulation of cancer stem cells (CSCs) which are capable of self-renewal, differentiation, and tumour-initiation. Previous studies have demonstrated that cancer stem cells are relatively resistant to chemo-and radio-therapies, and play an essential role in tumour recurrence and metastasis. Since multiple human malignancies are associated with quantitative and qualitative deficiencies in the immune system, immunotherapies are potentially ejective for cancer treatment. Vaccination is believed to have advantages over traditional tr... 
Journal of Vaccines & Vaccination has completed 8 years of successful journey, now we are in 9th year for continuing the excellence in the publication field with the help of our glorious editors. We are 
SYPHILIS
Syphilis is a highly contagious disease that’s mostly spread through sexual activity, including oral and anal sex. The infected person often doesn’t know that they have the disease and passes it on to their sexual partner.
Syphilis was once a major public health threat. It can cause serious long-term problems such as arthritis, brain damage, and blindness. There wasn’t an effective treatment until the late 1940s, when the antibiotic penicillin was developed. After the initial infection, the syphilis bacteria ca... 
Kidney Infection Diagnosis
Kidney infection, also known as renal infection or pyelonephritis, is a common type of urinary tract infection. Bacteria often infect the bladder or the urethra and spreads to one of the kidneys. Women are most commonly affected by kidney infection, as are pregnant mothers, children under 2 years of age, and individuals aged over 60 years. This article will explain the symptoms of a kidney infection and how it is diagnosed, prevented, and treated.
Some key points about kidney infections:
One of the kidney'... 
Pathophysiology
Pathophysiology is convergence of pathology with physiology – is the study of the disordered physiological processes that cause, result from, or are otherwise associated with a disease or injury. Pathology is the medical discipline that describes conditions typically observed during a disease state, whereas physiology is the biological discipline that describes processes or mechanisms operating within an organism. Pathology describes the abnormal or undesired condition, whereas pathophysiology seeks to explain the functional ... 
Hair cells, with the hallmark of the stereocilia bundle at their apical surface, are the sensory receptors of the auditory and vestibular systems in the ears of vertebrates. Hair cells transduce mechanical stimuli into electrical activity. In addition to the stereocilia bundle, hair cells also contain structural and functional specializations in the basolateral and synaptic membranes, which are responsible for electrical activities and synaptic transmission. The supporting cells in the sensory epithelium contribute to the mechanics and the homeostasis of the ionic and chemical environment i... 
Emerging Infectious Diseases and their Diagnosis
Infectious diseases are the world’s greatest killers that present one of the most significant health and security challenges facing the global community. In our daily life we are surrounded by a wealth of microorganisms, the majority of which are non-harmful, but some are severely harmful for the health. Infectious diseases are among the world’s leading causes of death, and scientists from every nation perform research, share information, build laboratory capacity in poorer nations and c... 
Journal of Antivirals & Antiretrovirals primary current therapeutic approach against viral diseases is to target viral components that are essential for replication. There are a number of disadvantages targeting viral components including the limited number of druggable viral targets because viruses have a small genome, as well as the rapid development of drug resistance. New drug therapies combine antivirals to increase efficacy and to avoid the development of drug resistant strains. These strategies are effective for viruses such as HIV, but clearly there is a need to expand our drug ... 
Journal of Infectious Diseases and Diagnosis Marks it’s Four Long Years of Journey by Announcing Discounts on Article Processing Charges
Creating Awareness on Infectious Diseases & their Diagnosis for a Better Tomorrow
On behalf of the Journal of Infectious Diseases and Diagnosis, as Editor-in-Chief, it is my distinct honour and privilege to inform you that, it’s been ten long years we have started the Journal, now we are celebrating the 04th Anniversary and we are privileged to welcome eminent Scientists from this field to our journal. As Editor-In-Chief it is my great pleasure and honour to welcome you to the Journal of Infectious Diseases and Diagnosis (JIDD).
The ... 
November 25, 2019, Spain: 
Journal of Women’s Health Care Marks its Eight Long Years of Journey by Announcing Discounts on Article Processing Charges
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Health Benefits of Probiotics
On behalf of the Journal of Probiotics & Health, as Editor-in-Chief, it is my distinct honour and privilege to i... 
HEALTH CARE: CURRENT REVIEWS
Disseminating the knowledge on Health Care Research
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