Automated drug design of kinase inhibitors
The Journal, Drug Designing: Open Access publishes the highest quality scientific articles amalgamating broad range of fields including molecular modeling, clinical research and drug discovery and delivery.
Drug Designing: Open Access is a peer-reviewed and open access journal with an aim to provide rapid and reliable source of information in the mode of original articles, review articles, case reports, short communications, etc. in all areas of the fi... Read More
Bioactive peptides play a crucial role in the physiology and biochemistry of life. Naturally occurring and designed peptides have been described as promising therapeutic tools with applications in medical therapies and diagnostics. They find use in multiple clinical situations, including oncologic, cardiovascular, metabolic, immunological and infectious diseases. As chemically diverse molecules, the use of peptides in clinics offers a number of advantages as therapeutic agents when compared to small molecule drugs. Their specific binding to a diversity of biological targets results in high ... 
EYE DISORDERS
Dramatic advances in biotechnology are revolutionizing medical science with recent discoveries in cellular and tissue engineering and new drug delivery techniques. There is now great potential to improve medical care by enhancing diagnostic capabilities and substantially expanding therapeutic options. Over the past decade, the pace of biotechnological research has markedly accelerated, especially in the field of ophthalmology, which has never been more exciting or promising. We stand on the threshold of capabilities that will diminish or prevent visu... 
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If "drugs" have been defined as compounds used in the treatment and prevention of diseases, or are intended to affect a physiological function, "cosmetics" have been labelled as substances that clean or enhance the appearance of the skin without therapeutic benefits. There is also a grey area bordering these two fields, for which the term "cosmeceuticals" has been defined. “Cosmeceuticals” are described as hybrids between drugs and cosmetic products which are able to enhance both health and beauty of the skin by external application. Cosmeceuticals,... 
The Journal, 
Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is evident that the scientific community must come together to mitigate the many clinical and public health management challenges.
The COVID-19 outbreak poses global pressure on modern societies and particularly healthcare related infrastructure. Nanotechnology brings new prospects for developing affordable and scalable detection methods, safe personal protection equipment and new effective medical solutions.
Nanosensors are already a ... 
Recent discoveries in nanotechnology are promoting a growing revolution across all area of medicine through the tailoring of structures and functionalities of biomaterials at extremely small scales (similar to most biomolecules). At the nanoscale quantum mechanics takes over from classical mechanics, thus nanomaterials have unique behaviors. For instance, the huge surface area of nanomaterials allows nanoscale materials to better interact with, and locally manipulate, cells. This provides us with unprecedented tools for disease prevention, diagnosis, and treatment.
Nanomateri... 
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Medication adherence is the process by which patients take their medication as prescribed and is an umbrella term that encompasses all aspects of medication use patterns. Patient adherence is a prerequisite for achieving the therapeutic outcome. Further, precise knowledge of medication intake is crucial for any evaluation of drug effectiveness. With the emergence of electronic records (in hospitals or clinics, at GPs or community pharmacies) and new technologies for electronic monitoring, medical data became electronically available and could deliver surrogate values of medication intake. C... 
Emergence of MDR (multidrug resistant) strains of microorganisms is one of the most worrying challenges in current public health sectors. While most of the popular antibiotics/antimicrobial agents continue to lose efficacy against a range of microbial strains including malaria, TB (tuberculosis), leprosy, hepatitis, meningococcus, strains causing nosocomial infections like Ps. aeruginosa and HIV (human immunodeficiency virus) causing AIDS (acquired immunodeficiency syndrome), the current scenario of arrival of new antibiotic molecules in the market is less than inspiring.... 
Vitiligo
Vitiligo is a complex disease, involving a combination of genetic and environmental factors, together with metabolic and immune alterations. Abnormalities leading to impaired melanocyte regeneration and/or proliferation suggest that defect(s) in melanocytes play an important role in this disease. However, it is becoming increasingly evident that inflammation and autoimmunity are also central players, in particular during the progressive phase of the disease. The critical role of the immune response during vitiligo pathogenesis has now largely been describ... 
Immunology | History
In the highly competitive world of biomedical science, often the rush to publish and to be recognized as “first” with a new discovery, concept or method, is lost in the hurly-burly of the moment, as “the maddening crowd” moves on to the next “new thing”. One of the great things about immunology today is that it has only become mature as a science within the last half-century, and especially within the past 35 years as a consequence of the revolution of molecular immunology, which has taken place only since 1... 
The Journal of Developing Drugs is an open access and International, Peer reviewed Journal that aims to disseminate knowledge and promote discussion on all topics related to Drug development which deals with Drug Interaction, Drug Metabolism, Drug discovery, Pharmaceutical chemistry, heterocyclic chemistry, medicinal chemistry. The open access journal is published by Longdom Publishing who hosts around 350 open access peer-reviewed journals as well as organizes more than 100 International scientific Conferences.
The journal also covers Pharmacy Practice, Pharmacology,... 
Asian Journal of Pharmaceutical Technology and Innovation is an open access Scientific Journal which mainly focuses on articles of Pharmacy. The Asian Journal of Pharmaceutical Technology and Innovation comes up with an opportunity to researchers and scientist to explore advance research in Drug Development.
The editorial team of Asian Journal of Pharmaceutical Technology and Innovation and Research is overwhelmed by the response and eagerness of the academic and research contributors to publish with the journal. During this year we look forward to taking some initiates that would... 
Journal of Developing Drugs is an open access Scientific Journal which mainly focuses on articles of Drug designing. The 
Journal of Developing Drugs is a peer-reviewed, open access journal that reflects articles on all types of Drugs and Medicine. The journal welcomes submissions from all related fields of Drugs including advances in medicines.
Articles will be also considered from related analysis from Drug Metabolism, Drug Delivery Systems, Drug Interactions, Drug Therapy, Drug Addiction, Pharmaceutical Industry, chemistry. Submission of important articles containing advanced research output aiding in forwarding the subject are most welcome. The wide scope of the journal will aid in contributing a... 
The field of cytokines and their role in intestinal immunity has expanded tremendously in the last two decades. Since the discovery of interleukin-1 (IL-1) in 1984, a variety of cytokines and cytokine factors have been discovered and cloned. There are now 40 interleukins and several TNF-family members identified that signal through specific receptors and possess pleiotrophic biological activities, in many instances. There is strong evidence that cytokines play a critical role during intestinal immunity, and their role as mediators of intestinal immune responses to infectious agents includin... 
The editorial team of Journal of Developing Drugs is overwhelmed by the response and eagerness of the academic and research contributors to publish with the journal and take part in the year-long celebrations. During this year we look forward to taking some initiates that would encourage and reward our prospective customers. It gives us great pleasure in announcing the call for paper on the 9th Anniversary of the Journal at special and hefty discount of up to 20 percent on one-time article processing charge.
Prospective academicians and scientists are encoura... 
Journal of 
Journal of 
Journal of Developing Drugs, a peer reviewed, Open Access Journal provides an open platform for eminent scientists around the globe to publish their scholarly work in field related to Drugs. Various regulatory approaches for toxic chemicals management are included in scope of Journal of Developing Drugs.
Journal of Developing Drugs is an open access, peer reviewed international journal with a primary objective to provide research and applications related to Pharmaceutical & Toxicology Sciences.
The Journal deals with surgery, internal medicine, ca... 
T Cell-Dependent in situ Initiation and Systemic Regulation Model ofImmune Responses
Hypothesis: A peripheral initiation and systemic response model of immunity.Very few antigen presenting cells (APCs) are able to elicit an immuneresponse. We suggest, that peripheral immune activation, e.g. via theskin, may induce parallel co-migration of dendritic cells (DC’s) andactivated antigen-specific T cells to the draining lymph nodes andbeyond. Herewith, memory-like anti-foreign-reactive T cells inaddition or even superior to naïve T cells once... 
Androgen Receptor as Prognostic Marker in Triple-Negative Breast Cancer Patients
Purpose: The purpose of this study was to assess the prognostic impact of androgen receptor (AR) expression in patients with triple-negative breast cancer (TNBC).
Methods/patients: 101 patients treated for primary TNBC without distant metastasis from 1999 to 2015 were identified from breast surgery database. Kaplan-Meier and Cox regression models evaluated disease-free survival (DFS) and overall survival (OS).
Results:... 
Objective: Phytochemical constituents of herbal extracts has shown positive response of antioxidant activity. The purpose of the present study was to investigate the antioxidant activity of polyphenolic flavonoids in the ethanolic extract of stem of Nicotiana tabacum.
Materials and Methods: Flavonoids contents were determined by both thin layer chromatography and aluminium chloride colorimetric method, where as phenolic content was determine by Folin-Ciocalteau method. Antioxidant activity was observed by determin... 
Lentinan Exerts its Anti-Inflammatory Activity by Suppressing TNFR1 Transfer to the Surface of Intestinal Epithelial Cells through Dectin-1 in an in vitro and mice model
It has been reported that lentinan, β-1,3; 1,6-glucan derived from Lentinula edodes, suppresses intestinal inflammation and ameliorates symptoms of colitis. However, the mechanism of intestinal anti-inflammatory activity of lentinan and how it is recognized by intestinal epithelial cells remains largely unclear. The receptor for lentinan on intestinal epithelial cells was identified using an ... 
Developing Electronic-nose Technologies for Clinical Practice
The development of relatively simple gas-sensing devices with sensor arrays capable of constructing molecular profiles of complex Volatile Organic Compound (VOC) metabolites from clinical samples, based on production of healthy or disease-specific digital signature patterns, may soon help to revolutionize diagnostic procedures in clinical practice. This mini-review summarizes the development of recent portable electronic-nose (e-nose) technologies as new diagnostic tools with the potential for accelerat... 
The Journal 
Commentary on “Gallbladder Cancer: South American Experience
When I was invited by Dr. Ghassan Abou-Alfa to write an article about the South American experience in gallbladder cancer (GC) I felt enthusiasm. It was an opportunity to make a contribution to this public health problem. GC is among the leading causes of death from cancer in women in many Western areas in my country Argentina and in South America. Based on their daily practice experience many health workers in Salta, the province where I live at the northwest of Argentina, know that GC is a loc... 
MicroRNAs in Skin Biology: Biogenesis, Regulations and Functions in Homeostasis and Diseases
The progression in science gives novel and deeper understandings of human beings organisms. The Human Genome Project uncovered about 20,500 human genes. More recently, non-coding RNAs saw the light and gained researchers interest. Among the different subsets of these non-coding RNAs, microRNAs were identified as 18-25 nucleotides long and have been shown to play critical regulatory roles in a wide range of cellular processes. Emerging studies highlighted the importance of ... 
Parathyroid Carcinoma has a PD-L1 Expression, and Share with Atypical Neoplasms an Abundant Intratumoral Macrophagic
Aim: The aim of this study was characterized programmed death-ligand 1 (PD-L1) expression and tumoralinfiltrating lymphocytes (TILs) in parathyroid carcinoma (PC) and atypical parathyroid neoplasms (ANs).
Methods: Our tissue samples constitute 30 parathyroid tumors (17 PC and 13 ANs) which were available from a prospectively collected database at the University of Texas M.D Anderson Cancer Center from 1... 
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The Journal, 
Journal of Developing Drugs is a peer-reviewed Journal, encourages on-going international research and information exchange through publication of latest advances.
The Journal is pleased to inform that it is been running successfully since 8 years and is running towards its 9th Anniversary. It is an Open access scholarly Developing Drugs journal with an ISSN No: 2329-6631. This journal is known for its quality research articles in the field of Pharmaceutics, Nanotechnology, Novel Drug Delivery Systems, Quality Control, Quality Assurance, International Regulatory, ... 
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Journal of 
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The perspective of the 
Journal of Developing Drugs is an open access Scientific Journal which mainly focuses on articles of Drug designing. The 
Scope of Drug Designing: Open Access Journal
Statistical Designs for Pharmaceutical
Risk Factors for Febrile Seizures in Children
Objective: we aimed to identify the factors associated with febrile seizures (FS) occurrence.
Methods: This was a case-control study. Sixty cases of FS were prospectively recorded and compared to 60 controls admitted for fever without seizures. Baseline Data were collected from all consecutive patients and laboratory hematological parameters including complete blood count, serum iron, serum ferritin and zinc levels were perform... 
The Presence of Autonomous and Non-Autonomous Replication in Cancer and their Connection through Inflammation
Targeted therapy with small molecule such as TKI (tyrosine kinase inhibitor) against EGFR has achieved high response rate and significant clinical benefits in selected group of lung cancer patients in the past decade. One reliable criterion for patient selection is the presence of certain mutations in the EGFR gene such as mutations in exon-19, 20 or 21 in lung cancer patients. In these patients, it is often observed that TKI therapy could be so effective ... 
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Special Issue on Drug Designing : Edited by Guest Editors
The 
Pemphigus Herpetiformis with Only Positive Anti-Envoplakin Antibodies
Pemphigus herpetiformis, first described in 1975, is a rare subtype of autoimmune bullous disease that associates clinical features of dermatitis herpetiformis with immunological features of pemphigus. We present a 48-years-old female patient, with pruritic lesions located mainly in the upper limbs with 6 years of evolution. Physical examination revealed erythematous papules, some excoriated and vesicles of translucent content distributed on her arms, trunk and neck. Histological examination of ... 
Autoimmune Hemolytic Anemia and Thrombocytopenia with Tuberculous Lymphadenitis
Well-differentiated small-intestinal neuroendocrine tumors (SI-NETs) tend to be biologically indolent.Despite this tendency, they have a predilection for metastasis. Peritoneal involvement is quite common as isunfortunately peritoneal carcinomatosis (PC). PC is a dreaded metastatic complication due to the significant morbidity it creates for patients as well as well as increasing their mortality risk. The risk factors for PC development in SI-NETs remain understudied; however, on... 
Journal of Drug Designing: Open Access | Celebrating 9th Anniversary
Journal of Biology and Todays World is a perfect Insight for the readers related to Biology and Medicine. It has a vast scope and is currently running since 8 years with many successful quality articles published. Due its broad scope, a diverse set of topics, such as genetics, biotechnology, biochemistry, microbiology, cellular & molecular biology, and disease biology, are covered under the aegis of this journal. Additionally, the journal also provides rapid, authoritative, and insightful reports and interpretation of topical and future trends in science.
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Highlights on Drug Designing
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Reviewing the progression in Drug Designing research
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Pathology: A big innovation to medicine
Journal of Medical and Surgical Pathology (JMSP) has announced almost 20 percent discount on article processing charge to commemorate its 4th Anniversary.
The Editorial Board of Journal of Medical and Surgical Pathology is overwhelmed by the response and eagerness of the academic and research contributors to publish with the journal and take part in the 4th anniversary celebrations. During this year we look forward to taking some initiatives that would encourage and rewar... 
On behalf of the Journal of Developing Drugs, as Editor-in-Chief, it is my distinct honour and privilege to inform you that, it’s been ten long years we have started the Journal, now we are celebrating the 
Alopecia is not a well-known adverse effect of second-line anti-tuberculosis drugs. It is, however, been frequently reported in Eritrea and 83% of the reports of alopecia associated with second-line anti-TB drugs in the global adverse drug reaction database, as of July 25, 2017, were submitted from Eritrea. It is wondering why this much variation is happening and this study is therefore aimed at quantifying the risk, identifying possible risk factors and elucidating the causal association between alopecia and the second-line anti-TB drugs in Eritrea. This was an observational cohort study o... 
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