Glioblastoma-Diagnosis and Treatment

Image Glioblastoma-Diagnosis and Treatment Journal of Cancer Research and Immuno-Oncology is an open access rapid peer reviewed journal in the field of cancer research. Here we discuss about Glioblastoma- Diagnosis and Treatment. Glioblastoma is an aggressive type of cancer that can occur in the brain or spinal cord. Glioblastoma forms from cells called astrocytes that support nerve cells. Glioblastoma can occur at any age, but tends to occur more often in older adults. It can cause worsening headaches, nausea, vomiting and seizures.... Read More

Role of Carcinogen in the Formation of Cancer

Image Role of Carcinogen in the Formation of Cancer Journal of Cancer Research and Immuno-Oncology is an open access rapid peer reviewed journal in the field of cancer research. Here we discuss about the Role of Carcinogen in the Formation of Cancer A carcinogen is any substance, radionuclide, or radiation that promotes carcinogenesis, the formation of cancer. This may be due to the ability to damage the genome or to the disruption of cellular metabolic processes. Several radioactive subst... Read More

Research uncovers clues in use of immunotherapy for breast cancer

Image UC researchers have found a potential new combination therapy for breast cancer that would integrate use of the body's immune system with targeted treatment for a particular protein that advances cancer. The study, published in the journal Cancer Research, a journal of the American Association for Cancer Research, provides data that could eventually lead to a new breast cancer therapy, says co-lead author Syn Kok Yeo, Ph.D., research instructor in the department of cancer biology and a member in the lab of Jun-Lin Guan, the Francis Brunning Professor and Cancer Biology Departm... Read More

Single-gene treatment cures mice of Parkinson's within three months

Image While there are ways to alleviate some symptoms, there is currently no way to prevent or cure Parkinson’s disease, so the prospect of a one-off treatment that completely eliminates it is certainly an exciting one. While such a therapy remains a while off, scientists have demonstrated an exciting proof of concept in mice, whereby inhibiting a single gene as a one-time treatment eradicated the disease entirely, and kept it at bay for the remainder of their lives. The research was carried out at the University of California, San Diego (UCSD), and centers on a protein called PTB... Read More

Brain tumor- Symptoms, Risk factors

Image Brain tumor- Symptoms, Risk factors Journal of Cancer Research and Immuno-Oncology is an open access rapid peer reviewed journal in the field of cancer research. Here we discuss about Brain tumor- Symptoms, Risk factors. A brain tumor is a mass or growth of abnormal cells in your brain. Many different types of brain tumors exist. Some brain tumors are noncancerous (benign), and some brain tumors are cancerous (malignant). Brain tumors can begin in your brain (primary brain tumors), or cancer can begin in other parts of your body and spread to y... Read More

Adenosarcoma || Types and Treatment

Image Adenosarcoma || Types and Treatment Journal of Cancer Research and Immuno-Oncology is an open access rapid peer reviewed journal in the field of cancer research. Here we discuss about Adenosarcoma || Types and Treatment. Adenosarcoma (also Mullerian Adenosarcoma) is a rare malignant tumor that occurs in women of all age groups, but most commonly post-menopause. Adenosarcoma arises from mesenchymal tissue and has a mixture of the tumoral components of an adenoma, a tumor of epithelial origin, and a&... Read More

Researchers destroy cancer cells with ultrasound treatment

Image An international research team led by Dr. Tali Ilovitsh of the Biomedical Engineering Department at Tel Aviv University developed a noninvasive technology platform for gene delivery into breast cancer cells. The technique combines ultrasound with tumor-targeted microbubbles. Once the ultrasound is activated, the microbubbles explode like smart and targeted warheads, creating holes in cancer cells' membranes, enabling gene delivery. Conducted over two years, the research was published on June 9 in the journal Proceedings of the National Academy of Sciences (PNAS). Dr. Ilovitsh ... Read More

Better cancer cell detection using magnetic nanoparticles

Image Griffith University researchers, in collaboration with the University of Queensland, have identified magnetic nanoparticles, nanozymes, which could help in the detection of cancer. Researchers discovered the gold-loaded iron oxide nanozymes enhance the signal for cancer detection in breast cells by six-fold. There are biomarkers or receptors expressed on the surface of healthy or cancer cells,” explained ... Read More

Hemophagocytic lymphohistiocytosis- Signs, Symptoms, Diagnosis and Treatment

Image Hemophagocytic lymphohistiocytosis- Signs, Symptoms, Diagnosis and Treatment Journal of Cancer Research and Immuno-Oncology is an open access rapid peer reviewed journal in the field of cancer research. Here we discuss about Hemophagocytic lymphohistiocytosis- Signs, Symptoms, Diagnosis and Treatment. Hemophagocytic lymphohistiocytosis (HLH), also known as Hemophagocytic lymphohistiocytosis is an uncommon hematologic disorder seen more often in children than in adults. It is a life-threatening di... Read More

This vaccine may protect against worst symptoms of COVID-19

Image The MMR (measles, mumps, rubella) vaccine could serve as a preventive measure to dampen septic inflammation associated with COVID-19 infection, say researchers. According to the study, published in the journal mBio, vaccination with MMR in immunocompetent individuals has no contraindications and may be especially effective for health care workers who can easily be exposed to COVID-19. "Live attenuated vaccines seemingly have some nonspecific benefits as well as immunity to the target pathogen. A clinical trial with MMR in high-risk populations may provide a low-risk... Read More

Inflammatory Breast Cancer- Signs, symptoms and treatment

Image Inflammatory Breast Cancer- Signs, symptoms and treatment Journal of Cancer Research and Immuno-Oncology is an open access rapid peer reviewed journal in the field of cancer research. Here we discuss about Inflammatory Breast Cancer- Signs, symptoms and treatment. Inflammatory breast cancer (IBC) is rare and accounts for only 1-5% of all breast cancers. Although it is often a type of invasive ductal carcinoma, it differs from other types of breast cancer in its symptoms, outlook, and treatment. IBC symptoms are caused by cancer cells blocking lymph ... Read More

Allogeneic stem cell transplant

Image Allogeneic stem cell transplant Journal of Cancer Research and Immuno-Oncology is an open access rapid peer reviewed journal in the field of cancer research. It is a bimonthly journal. Here we discuss about Allogeneic stem cell transplant. An allogeneic stem cell transplant uses healthy blood stem cells from a donor to replace your diseased or damaged bone marrow. An allogeneic stem cell transplant is also called an allogeneic bone marrow transplant. A donor may be a family member, an acquaintance or someone you don't know. The blood stem c... Read More

Acute myelogenous leukemia – Symptoms, Diagnosis and Treatment

Image Acute myelogenous leukemia – Symptoms, Diagnosis and Treatment Journal of Cancer Research and Immuno-Oncology is an open access rapid peer reviewed journal in the field of cancer research. It is a bimonthly journal. Here we discuss about acute myelogenous leukemia – Symptoms, Diagnosis and Treatment. Acute myelogenous leukemia (AML) is a cancer of the blood and bone marrow — the spongy tissue inside bones where blood cells are made. The word "acute" in acute myelogenous leukemia denotes the disease's rapid progre... Read More

Synthesized Cell Culture Process Could Make for More Efficient Cancer Research

Image Researchers in Japan have replicated cancer cells from diseased bladder tissue in dogs, minimizing the use of costly stem cell products. The synthesized tumor cells allow scientists to diagnose cancer and optimize treatment without putting the patient through tiresome rigors of chemotherapy trial and error. The research team led by Senior Assistant Professor Tatsuya Usui from the Laboratory of Veterinary Pharmacology at the Tokyo University of Agriculture and Technology published their findings in the journal Scientific Reports on June 10th, 2020. Organoids are a niche w... Read More

A good vitamin D status can protect against cancer

Image Summary: A good vitamin D status is beneficial both in cancer prevention and in the prognosis of several cancers, according to a new research review. The anti-cancer effects of vitamin D are especially pronounced in the prevention and treatment of colon cancer and blood cancers. In addition, high vitamin D responsiveness can be linked to a smaller cancer risk. Vitamin D responsiveness varies between individuals, affecting their need for vitamin D supplementation. A good vitamin D status is beneficial both in cancer prevention and in the prognosis of several cancer... Read More

Lung cancer - Symptoms and causes

Image Lung cancer - Symptoms and causes Journal of Cancer Research and Immuno-Oncology is an open access rapid peer reviewed journal in the field of cancer research. It is a bimonthly journal.  Below we discuss about Lung cancer - Symptoms and causes. Lung cancer is a type of cancer that begins in the lungs. Your lungs are two spongy organs in your chest that take in oxygen when you inhale and release carbon dioxide when you exhale. Lung cancer is the leading cause of cancer deaths worldwide. People who smoke have the greatest risk of ... Read More

Mammography | Purpose and Risks

Image Mammography | Purpose and Risks Journal of Cancer Research and Immuno-Oncology is an open access rapid peer reviewed journal in the field of cancer research. It is a bimonthly journal.  Below we discuss about Sarcoma –Symptoms, Causes and Treatment. Definition Mammography is the study of the breast using x ray. The actual test is called a  mammogram. There are two types of mammograms. A screening&nb... Read More

Sarcoma –Symptoms, Causes and Treatment

Image Sarcoma –Symptoms, Causes and Treatment Journal of Cancer Research and Immuno-Oncology is an open access rapid peer reviewed journal in the field of cancer research. It is a bimonthly journal.  Below we discuss about Sarcoma –Symptoms, Causes and Treatment. Sarcoma is a type of cancer that can occur in various locations in your body. Sarcoma is the general term for a broad group of cancers that begin in the bones and in the soft (also called connective) tissues (soft tissue sarcoma). Soft tissue sarcoma forms in the tissues tha... Read More

Control of HIV-1 Pathogenesis in Viremic Nonprogressors Is Independent of Gag-Specific Cytotoxic T Lymphocyte Responses

Image Viremic nonprogressors (VNPs) constitute a very scarce group of untreated human immunodeficiency virus type 1 (HIV-1)-infected individuals who maintain stable CD4+ T cell counts despite high levels of HIV-1 replication. The specific factors associated with this atypical control of the HIV infection have been poorly described. Since specific T cell responses seem to be one of the main causes of HIV-1 control in elite controllers, we studied whether HIV-1 Gag-specific cytotoxic T lymphocyte (CTL) responses could also modulate disease control in VNPs. We characterized the immune responses from... Read More

The Inflammatory Syndrome Impacting COVID-19 Kids

Image Researchers and health officials are working quickly to study a new inflammatory health condition that’s impacting kids who’ve had coronavirus. In parts of the US and Europe, a small but increasing number of children have come down with symptoms similar to Kawasaki disease or toxic shock. Doctors have determined it’s a brand new condition, which they’ve officially dubbed “paediatric multisystem inflammatory syndrome.” It’s causing kids to develop fevers, as well as inflammation of the skin, blood vessels, and heart. The Centers for Disease Control a... Read More

Rheumatoid arthritis, Complications and Treatment

Image Rheumatoid arthritis, Complications and Treatment Journal of Cancer Research and Immuno-Oncology is an open access rapid peer reviewed journal in the field of cancer research. It is a bimonthly journal.  Below we discuss about Rheumatoid arthritis, Complications and Treatment  Rheumatoid arthritis is a chronic inflammatory disorder that can affect more than just your joints. In some people, the condition can damage a wide variety of body systems, including the skin, eyes, lungs, heart and blood vessels. An autoimmune disorder, rheumat... Read More

Colon cancer overview and Treatment

Image Colon cancer overview and Treatment Journal of Cancer Research and Immuno-Oncology is an open access rapid peer reviewed journal in the field of cancer research. It is a bimonthly journal.  Below we discuss about Colon cancer overview and Treatment. Colon cancer is a type of cancer that begins in the large intestine (colon). The colon is the final part of the digestive tract. Colon cancer typically affects older adults, though it can happen at any age. It usually begins as small, noncancerous (benign) clumps of cells called polyps t... Read More

Coronavirus vaccine

Image While the world grapples with the impact of the coronavirus pandemic, search for a vaccine in on. There have been many discussions and debates on a potential cure, however, almost all stakeholders seem to agree that the coronavirus vaccine could take at least around 6-9 months. Efforts are being made globally for ways to overcome the disease. Top American immunologist and physician Dr Anthony Fauci also said that it could take a year to 18 months for a vaccine to develop. England's Chief Medical Officer Chris Whitty said that the chances of creating a highly effective vaccine ... Read More

Potential coronavirus vaccine enters human testing

Image United States-based pharmaceutical giant Pfizer has begun testing multiple versions of an experimental vaccine in healthy young people in America. Pfizer has partnered with Germany's BioNTech SE to explore a potential defense against the respiratory disease over 2.5 lakh people worldwide, Wall Street Journal reported. Researchers at the New York University Grossman School of Medicine in Manhattan and the University of Maryland School of Medicine in Baltimore on Tuesday said that they have begun injecting volunteers with the first of four vaccine candidates from Pfize... Read More

Breast cancer overview and Treatment

Image Breast cancer Over view and Treatment Journal of Cancer Research and Immuno-Oncology is an open access rapid peer reviewed journal in the field of cancer research. It is a bimonthly journal.  Below we discuss about Breast cancer overview and Treatment. Cancer occurs when changes called mutations take place in genes that regulate cell growth. The mutations let the cells divide and multiply in an uncontrolled way. Breast cancer is cancer that develops in breast cells. Typically, the cancer forms in either the lob... Read More

Chemotherapy to Treat Cancer

Image Chemotherapy to Treat Cancer Journal of Cancer Research and Immuno-Oncology is an open access rapid peer reviewed journal in the field of cancer research. It is a bimonthly journal.  Below we discuss about Chemotherapy to Treat Cancer. Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body Chemotherapy refers to the use of any drug to treat any disease. But to most people, the word chemotherapy (or "chemo") means drugs used for cancer treatment. It's impo... Read More

Over a third of coronavirus patients show neurological symptoms, study reports

Image As case numbers of COVID-19 continue to rise around the world, we are starting to see an increasing number of reports of neurological symptoms. Some studies report that over a third of patients show neurological symptoms. In the vast majority of cases, COVID-19 is a respiratory infection that causes fever, aches, tiredness, sore throat, cough, and, in more severe cases, shortness of breath and respiratory distress. Yet we now understand that COVID-19 can also infect cells outside of the respiratory tract and cause a wide range of symptoms from the gastrointestinal disease (diarrhe... Read More

Could ‘Innate Immunology’ Save Us From the Coronavirus?

Image As the world waits for a coronavirus vaccine, tens of thousands of people could die. But some scientists believe a vaccine might already exist. Surprising new research in a niche area of immunology suggests that certain live vaccines that have been around for decades could, possibly, protect against the coronavirus. The theory is that these vaccines could make people less likely to experience serious symptoms — or even any symptoms — if they catch it. At more than 25 universities and clinical centers around the world, researchers have begun clinical trials, p... Read More

Human Mesenchymal Stem Cell Transfusion for End Stage Liver Disease

Image Human Mesenchymal Stem Cell Transfusion for End Stage Liver Disease Journal of Cancer Research and Immuno-Oncology is an open access rapid peer reviewed journal in the field of cancer research. It is a bimonthly journal.  In its 1st issue of 1st volume Journal of Cancer Research and Immuno-Oncology has published a case-report regarding Human Mesenchymal Stem Cell Transfusion for End Stage Liver Disease. Here we discuss a case report related to ESLD. End-Stage Liver Disease (ESLD) is major health problems worldwide; it... Read More

Warm, humid climate linked to slower COVID-19 transmission: MIT Study

Image A warm and humid weather is linked to slower spread of the novel coronavirus, according to a study which suggests that Asian countries experiencing monsoon may experience lesser transmission of the virus. The scientists, including Qasim Bukhari from the Massachusetts Institute of Technology (MIT) in the US, assessed data on the number of COVID-19 infections in different parts of the world and compared it with two parameters of weather from all the regions - temperature and humidity. The findings, described in SSRN repository, show that 90 per cent of the novel coronavirus, SARS-Co... Read More

Artificial intelligence to enable fast-track review of COVID-19 research proposals

Image An Artificial Intelligence (AI) tool to help funders identify specialists to peer-review proposals for emergency COVID-19 research has been developed. It aims to help fast-track the allocation of funding, and in turn, accelerate the scientific response to the virus. The open-access publisher Frontiers has specifically developed the recommendation tool to aid funders during the crisis by helping them identify new reviewers. Under normal circumstances, the review process for research funding typically takes place by committee and can take a matter of months. However, since the COVID... Read More

Epigenetic Therapy, an Appealing Strategy to Improve Cancer Immunotherapy

Image Epigenetic Therapy, an Appealing Strategy to Improve Cancer Immunotherapy Journal of Cancer Research and Immuno-Oncology is an open access journal in the field of cancer research. It focuses on becoming one of the best peer reviewed journal in the field of cancer research Conventional chemotherapeutic regimens against tumors are subject to chemoresistance and drug-related toxicity. T cell-based immunotherapy is a particularly promising strategy for the treatment of malignant tumors because of its inherent high specificity and lymphocytes’ ability t... Read More

Iron Deficiency Anaemia

Image Iron Deficiency Anaemia Journal of Cancer Research and Immuno-Oncology is an open access journal in the field of cancer research. It focuses on becoming one of the best peer reviewed journal in the field of cancer research. Anaemia can be defined by a condition in which the total haemoglobin (Hb) level or number of red blood cells (RBCs) is poorly lowered. The World Health Organisation (WHO) defines anaemia as Hb<130 g/L in men older than 15 years, 110 g/L in pregnant women, and <120 g/L in non-pregnant women older than age 15 years. ... Read More

Study finds remdesivir effective against a key enzyme of coronavirus that causes COVID-19

Image Summary: Scientists have shown that the drug remdesivir is highly effective in stopping the replication mechanism of the coronavirus that causes COVID-19. The finding follows closely on research demonstrating how the drug worked against the Middle East Respiratory Syndrome (MERS) virus, a related coronavirus. Scientists at the University of Alberta have shown that the drug remdesivir is highly effective in stopping the replication mechanism of the coronavirus that causes COVID-19. The paper follows closely on research published by the same lab in late February that demon... Read More

FDA has approved saliva test to detect Covid-19 that lowers infection risk for health staff

Image From study showing effectiveness of remdesivir to another clinical trial for hydroxychloroquine, ThePrint brings you the latest on Covid-19 research. With studies and research being conducted around the world, understanding of the novel coronavirus and strategies to fight the pandemic are evolving every hour. ThePrint brings you a round-up of the latest research and development on Covid-19 from across the globe. Saliva test gets FDA approval The FDA has granted emergency use authorisation for a new coronavirus test ... Read More

Sertoli-Leydig Cell Tumor of the Ovary in a Postmenopausal Woman

Image Sertoli-Leydig Cell Tumor of the Ovary in a Postmenopausal Woman Journal of Cancer Research and Immuno-Oncology is an open access journal in the field of cancer research. It focuses on becoming one of the best peer reviewed journal in the field of cancer research. Journal of Cancer Research and Immuno-Oncology covers a broad scope for the authors to make their valuable contributions in cancer biology, tumor, radiology, metastasis, cancer immunotherapy, oncology, radiation therapy etc. By 2019, JCRIO has completed 5 years in publication with many peer rev... Read More

Cancer related fatigue and clinical outcome of dendritic cell vaccine in combination with cytokine-induced killer cell therapy in cancer patients

Image Cancer related fatigue and clinical outcome of dendritic cell vaccine in combination with cytokine-induced killer cell therapy in cancer patients Journal of Cancer Research and Immuno-Oncology is an open access journal in the field of cancer research. It focuses on becoming one of the best peer reviewed journal in the field of cancer research. Journal of Cancer Research and Immuno-Oncology covers a broad scope for the authors to make their valuable contributions in cancer biology, tumor, radiology, metastasis, cancer immunotherapy, oncology, radiation therapy etc... Read More

Coronavirus spread in China was twice faster than earlier assessment, US study says

Image Each person infected early in epidemic in Wuhan probably passed virus to average of 5.7 other people, says analysis by Los Alamos National Laboratory. Berlin: The new coronavirus raced through China much faster than previously thought, a U.S. research team said, suggesting that extremely widespread vaccination or immunity will be necessary to end the pandemic. Each person infected early in the epidemic in Wuhan probably passed the virus to an average of 5.7 other people, according to a mathematical analysis from Los Alamos National Laboratory. That&... Read More

New Coronavirus Drug Shows Promise in Animal Tests

Image An oral medicine was able to hinder the coronavirus behind COVID-19 as it attempted to replicate itself in human lung cells in test tubes, scientists reported Monday. It also hampered closely related coronaviruses from reproducing in mice for several days and improved their lung functions. The drug, called EIDD-2801, interferes with a key mechanism that allows the SARS-CoV-2 virus to reproduce in high numbers and cause infections, the researchers explained in the journal Science Translational Medicine. Human trials have not yet been done, but if the effect is similar... Read More

The T-Cell Predominance: Angioimmunoblastic T-Cell Lymphoma

Image The T-Cell Predominance: Angioimmunoblastic T-Cell Lymphoma Journal of Cancer Research and Immuno-Oncology is an open access peer reviewed journal in the field of cancer research. Journal of Cancer Research and Immuno-Oncology covers a broad scope for the authors to make their valuable contributions in cancer biology, tumor, radiology, metastatis, cancer immunotherapy, oncology, radiation therapy etc A lymph node based T-cell lymphoma which originates from a T follicular helper cell phenotype may cogitate the angio-immunoblastic T cell lymphoma (AITL) or... Read More

Delayed Immune-Related Erythrodermia in a Squamous NSCLC Patient Treated with Nivoluma

Image Delayed Immune-Related Erythrodermia in a Squamous NSCLC Patient Treated with Nivoluma Journal of Cancer Research and Immuno-Oncology is an open access peer reviewed journal in the field of cancer research. Journal of Cancer Research and Immuno-Oncology covers a broad scope for the authors to make their valuable contributions in cancer biology, tumor, radiology, metastatis, cancer immunotherapy, oncology, radiation therapy et Immunotherapy has been changing the scenario of the treatment of non-small cell lung cancer (NSCLC) and is leading to a dramatic i... Read More

Malaria Drug Helps Virus Patients Improve, in Small Study

Image A group of moderately ill people were given hydroxychloroquine, which appeared to ease their symptoms quickly, but more research is needed. The malaria drug hydroxychloroquine helped to speed the recovery of a small number of patients who were mildly ill from the coronavirus, doctors in China reported this week. Cough, fever and pneumonia went away faster, and the disease seemed less likely to turn severe in people who received hydroxychloroquine than in a comparison group not given the drug. The authors of the report said that the medication was promising, but that more... Read More

EXPERTS DISCUSS COVID-19 AND WAYS TO PREVENT SPREAD OF DISEASE

Image Experts from Johns Hopkins University met today for a webcast discussion of the latest developments in the ongoing coronavirus outbreak, including efforts to study the virus and methods of reducing the spread of illness. The conversation was moderated by Joshua Sharfstein, vice dean of public health practice and community engagement for the Bloomberg School of Public Health. Virologist Andy Pekosz, an expert in microbiology and immunology, provided an update on the status of two vaccine trials, the first of which began this week in Washington state and the second of whic... Read More

Journal of Cancer Research and Immuno-Oncology

Image Journal of Cancer Research and Immuno-Oncology is a fast-developing open access journal in the field of cancer research. It is a peer reviewed journal in the field of cancer research. Journal of Cancer Research and Immuno-Oncology covers a broad scope for the authors to make their valuable contributions in cancer biology, tumor, radiology, metastatis, cancer immunotherapy, oncology, radiation therapy etc This Journal provides a unique forum dedicated to scientists to express their research articles, review articles, case reports and short communications on any array of latest canc... Read More

Co-expression of PD-L1 Antibodies Enhances the Anti-Tumor Efficacy of Chimeric Antigen Receptor T Cells

Image Co-expression of PD-L1 Antibodies Enhances the Anti-Tumor Efficacy of Chimeric Antigen Receptor T Cells Journal of Cancer Research and Immuno-Oncology is a fast-developing open access journal in the field of cancer research. It focuses on becoming one of the best peer reviewed journal in the field of cancer research. Journal of Cancer Research and Immuno-Oncology covers a broad scope for the authors to make their valuable contributions in cancer biology, tumor, radiology, metastatis, cancer immunotherapy, oncology, radiation therapy etc This Journal prov... Read More

How to boost immune response to vaccines in older people

Image SUMMARY: Identifying interventions that improve vaccine efficacy in older persons is vital to deliver healthy aging for an aging population. Immunologists have identified a route for counteracting the age-related loss of two key immune cell types by using genital wart cream to boost immune response to vaccination in aged mice. After this validation in mice, the findings offer an attractive intervention to tailor the make-up of vaccines for older people. Research just published by the Linterman lab shows that the immune system of older mice can be given a helping h... Read More

Antibody Therapeutics in Oncology

Image Journal of Cancer Research and Immuno-Oncology is a fast-developing open access journal in the field of cancer research. It is a Peer Reviewed Open Access Journal supported by universally prominent Editorial Board members.. Journal of Cancer Research and Immuno-Oncology covers a broad scope for the authors to make their valuable contributions in cancer biology, tumor, radiology, metastatis, cancer immunotherapy, oncology, radiation therapy etc. This Journal provides a unique forum dedicated to scientists to express their research articles, review articles, case reports and short c... Read More

Human Intestinal Mononuclear Phagocytes in Health and Inflammatory Bowel Disease

Image Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a complex immune-mediated disease of the gastrointestinal tract that increases morbidity and negatively influences the quality of life. Intestinal mononuclear phagocytes (MNPs) have a crucial role in maintaining epithelial barrier integrity while controlling pathogen invasion by activating an appropriate immune response. However, in genetically predisposed individuals, uncontrolled immune activation to intestinal flora is thought to underlie the chronic mucosal inflammation that can ultimately result ... Read More

ACE2 expression by colonic epithelial cells is associated with viral infection, immunity and energy metabolism

Image Respiratory disease caused by the 2019 novel coronavirus (2019-nCoV) pneumonia first emerged in Wuhan, Hubei Province, China, in December 2019 and spread rapidly to other provinces and other countries. Angiotensin-converting enzyme 2 (ACE2) is the receptor for SARS-CoV and has been suggested to be also the receptor for 2019-nCoV. Paradoxically, ACE2 expression in the lung protects mice from SARS-CoV spike protein induced lung injury by attenuating the renin-angiotensin system. In the intestine, ACE2 also suppresses intestinal inflammation by maintaining amino acid homeostasis, antimicrobial... Read More

Isolevuglandins promote autoimmunity and hypertension in systemic lupus erythematosus

Image Hypertension, vascular inflammation and renal inflammation are characteristic of systemic lupus erythematosus (SLE), a multisystem autoimmune disease that is complex and poorly understood. Oxidation products of arachidonic and other fatty acids, termed isolevuglandins (isoLG) lead to formation of post-translational protein modifications that are immunogenic. We demonstrate isoLG enrichment in dendritic cells (DCs), B cells, and plasma cells from juvenile female B6.SLE123 mice. In adult B6.SLE123 and NZBWF1 mice, isoLG adducts are enriched in plasma cells and splenic DCs compared to C57Bl/6 ... Read More

Association Study of PTPN22 (rs2476601) and PADI4 (rs2240340) Polymorphisms with Rheumatoid Arthritis in Algerian Population

Image An association between protein tyrosine phosphatase 22 (PTPN22) and Peptidylarginine deiminase 4 (PADI4) genes with rheumatoid arthritis (RA) has been demonstrated in several populations. The present study investigated whether PTPN22 and PADI4 genes polymorphisms were involved in the genetic predisposition to RA in the Algerian patients. Materials and methods: The PADI4_94 (rs2240340) and the PTPN22 (rs2476601) Single Nucleotide Polymorphisms (SNPs) were genotyped in 300 RA patients and 306 healthy controls by real time polymerase chain reaction method (TaqMan Assa... Read More

Type I and II Interferon are Associated with High Expression of the Hippo Pathway Family Member's

Image The Hippo pathway plays a regulatory role on inflammation and cell death and proliferation. Here we described a relationship between Hippo pathway components and inflammation in healthy subjects. The plasma levels of cytokines and chemokines were used to define their inflammatory profile and classify them as normal, high and low producers of cytokines. Leukocytes from healthy subjects with inflammatory profile expressed the highest levels of MSTS1/MST2, SAV1, LATS1/LATS2, MOB1A/MOB1B and YAP genes. The group that overexpressed Hippo pathway-related genes secreted more IFN-ϒ and IFN-&a... Read More

Type I and II Interferon are Associated with High Expression of the Hippo Pathway Family Members

Image The Hippo pathway plays a regulatory role on inflammation and cell death and proliferation. Here we described a relationship between Hippo pathway components and inflammation in healthy subjects. The plasma levels of cytokines and chemokines were used to define their inflammatory profile and classify them as normal, high and low producers of cytokines. Leukocytes from healthy subjects with inflammatory profile expressed the highest levels of MSTS1/MST2, SAV1, LATS1/LATS2, MOB1A/MOB1B and YAP genes. The group that overexpressed Hippo pathway-related genes secreted more IFN-ϒ and IFN-&a... Read More

Increased Plasma Cells and Decreased B-cells in Tumor Infiltrating Lymphocytes are Associated with Worse Survival in Lung Adenocarcinoma

Image Introduction: Clinical significance of tumor-infiltrating plasma cells and B-cells in lung adenocarcinoma is not well known. Methods: CD3, CD20 and MUM1 immunostains were performed on representative tumor blocks selected from 120 consecutive lung adenocarcinoma cases treated by surgical resection at Mayo Clinic Rochester. CD3+ T-cells, CD20+ B-cells, and MUM1+ plasma cells were enumerated separately in the intraepithelial (IE) compartment and the stroma (ST) by digital image analyses using whole sections. Measured tumor-infiltrating plasma cells a... Read More

Increased Plasma Cells and Decreased B-cells in Tumor Infiltrating Lymphocytes are Associated with Worse Survival in Lung Adenocarcinomas : J Clin Cell Immunol

Image Introduction: Clinical significance of tumor-infiltrating plasma cells and B-cells in lung adenocarcinoma is not well known. Methods: CD3, CD20 and MUM1 immunostains were performed on representative tumor blocks selected from 120 consecutive lung adenocarcinoma cases treated by surgical resection at Mayo Clinic Rochester. CD3+ T-cells, CD20+ B-cells, and MUM1+ plasma cells were enumerated separately in the intraepithelial (IE) compartment and the stroma (ST) by digital image analyses using whole sections. Measured tumor-infiltrating plasma cells a... Read More

A Case Series of Rheumatic Immune-Related Adverse Events in Patients with Immune Check Point Inhibition

Image Background: Immune check point inhibitors (ICIs) have a potent anti-tumour effect and up to 43% of people receiving therapy will develop rheumatic adverse effects (RirAEs). People with pre-existing autoimmune disease (AID) were excluded from clinical trials. Aim: To define the characteristics of rheumatic symptoms in people on ICIs for malignancy and subsequent prescribed immunosuppression to manage adverse events. Methods: A case series formed from a retrospective audit of the Northern Territory Top End Health Service e... Read More

Increased Plasma Cells and Decreased B-cells in Tumor Infiltrating Lymphocytes are Associated with Worse Survival in Lung Adenocarcinomas

Image Introduction: Clinical significance of tumor-infiltrating plasma cells and B-cells in lung adenocarcinoma is not well known.  Methods: CD3, CD20 and MUM1 immunostains were performed on representative tumor blocks selected from 120 consecutive lung adenocarcinoma cases treated by surgical resection at Mayo Clinic Rochester. CD3+ T-cells, CD20+ B-cells, and MUM1+ plasma cells were enumerated separately in the intraepithelial (IE) compartment and the stroma (ST) by digital image analyses using w... Read More

On the Ambiguity of Firsts

Image The author, Stanley Shostak, on his article “On the Ambiguity of Firsts: Symbiogeny and Evolutionary Creativity”, states that he want to take issue with static concepts of origins. Predecessors of what exists at present are not necessarily what came first. The abstract of the article says: It isn’t as i... Read More

Special benefits on Publication as Journal of Stem Cell Research and Therapy completes its 9 year of Publication

Image Journal of Stem Cell Research and Therapy is about to complete its 9 years of Publication in the scientific field. During the span of 9 years it has provided a large platform for scientists, scholars, researchers with ease in publication process and gained lot of reputation among the scientific community which helps the journal ... Read More