A Study finds that Bat 'super immunity' may explain how bats carry coronaviruses

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Coronaviruses such as MERS, Severe Acute Respiratory Syndrome (SARS), and more recently the COVID19-causing SARS-CoV-2 virus, are thought to have originated in bats. While these viruses can cause serious and often fatal disease in people, for reasons not previously well understood, bats seem unharmed.

"Instead of killing bat cells as the virus does with human cells, the MERS coronavirus enters a long-term relationship with the host, maintained by the bat's unique 'super' immune system,"

"When a bat experiences stress to their immune system, it disrupts this immune system-virus balance and allows the virus to multiply,"

The research was carried out at USask's Vaccine and Infectious Disease Organization -- International Vaccine Centre, one of the world's largest containment level 3 research facilities, by a team of researchers from USask's Western College of Veterinary Medicine and VIDO-InterVac.

"We see that the MERS coronavirus can very quickly adapt itself to a particular niche, and although we do not completely understand what is going on, this demonstrates how coronaviruses are able to jump from species to species so effortlessly," So far, the SARS-CoV-2 virus has infected more than 3.5 million people worldwide and killed seven per cent of those infected. In contrast, the MERS virus infected nearly 2,500 people in 2012 but killed one in every three people infected. There is no vaccine for either SARS-CoV-2 or MERS. While camels are the known intermediate hosts of MERS-CoV, bats are suspected to be the ancestral host.

Coronaviruses rapidly adapt to the species they infect, but little is known on the molecular interactions of these viruses with their natural bat hosts. A 2017 USask-led study showed that bat coronaviruses can persist in their natural bat host for at least four months of hibernation.

When exposed to the MERS virus, bat cells adapt not by producing inflammation-causing proteins that are hallmarks of getting sick, but rather by maintaining a natural antiviral response, a function which shuts down in other species, including humans. Simultaneously, the MERS virus also adapts to the bat host cells by very rapidly mutating one specific gene, he said.

Operating together, these adaptations result in the virus remaining long-term in the bat but being rendered harmless until something such as disease or other stressors upsets this delicate equilibrium.

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