TranscriptLongdom Publishing is a total set of transcripts in a given organism and referred to as an expression profiling that examines the expression level of mRNAs in a given cell population. TranscriptLongdom Publishing includes high-throughput techniques based on DNA microarray. TranscriptLongdom Publishing:Open Access Journal is at higher echelons that enhance the intelligence and information dissemination on topics closely related to TranscriptLongdom Publishing. They provide a unique forum dedicated to scientists to express their research articles, review articles, case reports and short communications on an array of TranscriptLongdom Publishing. TranscriptLongdom Publishing:Open Access Peer Reviewed Journal is proficiently supported by universally prominent Editorial Board members.

The Journal is using Editorial Manager System for quality in review process.Editorial Manager System is an online manuscript submission, review and tracking systems. Review processing is performed by the editorial board members of TranscriptLongdom Publishing: Open Access or outside experts; at least two independent reviewers approval followed by editor approval is required for acceptance of any citable manuscript. Authors may submit manuscripts and track their progress through the system, hopefully to publication. Reviewers can download manuscripts and submit their opinions to the editor. Editors can manage the whole submission/review/revise/publish process.

Alzheimer’s disease is a pervasive neurodegenerative disorder, the molecular complexity of which remains poorly understood. Here, we analysed 80,660 single-nucleus transcriptomes from the prefrontal cortex of 48 individuals with varying degrees of Alzheimer’s disease pathology. Across six major brain cell types, we identified transcriptionally distinct subpopulations, including those associated with pathology and characterized by regulators of myelination, inflammation, and neuron survival. The strongest disease-associated changes appeared early in pathological progression and were highly cell-type specific, whereas genes upregulated at late stages were common across cell types and primarily involved in the global stress response. Notably, we found that female cells were overrepresented in disease-associated subpopulations, and that transcriptional responses were substantially different between sexes in several cell types, including oligodendrocytes. Overall, myelination-related processes were recurrently perturbed in multiple cell types, suggesting that myelination has a key role in Alzheimer’s disease pathophysiology. Our single-cell transcriptomic resource provides a blueprint for interrogating the molecular and cellular basis of Alzheimer’s disease.

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Transcriptomics: Open Access
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