Type-2 Diabetes Biomarkers

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Type 2 diabetes (T2D) is one of the most prevalent chronic diseases, affecting about 415 million people worldwide in 2015. The etiology of T2D involves an interaction between genetic predisposition and lifestyle (e.g. overweight, unhealthy diet, sedentariness).
The past decade has seen fast-paced, ...
Type 2 diabetes (T2D) is one of the most prevalent chronic diseases, affecting about 415 million people worldwide in 2015. The etiology of T2D involves an interaction between genetic predisposition and lifestyle (e.g. overweight, unhealthy diet, sedentariness).
The past decade has seen fast-paced, technology-driven developments in the field of complex disease genomics. Implementation of the genome wide association study approach has revolutionized our understanding of the genetic underpinnings of T2D, identifying ~70 genetic risk loci for T2D. However, these alone explain less than 10% of overall T2D risk and do not accurately predict T2D.
In the past five years, clinical studies of T2D have increasingly focused on identifying novel serum biomarkers for T2D using cutting-edge ‘omics’ tools, such as metabolomics and proteomics. Metabolomics approaches in particular have been widely adapted to screen blood or other human tissues for changes in metabolites and low-molecular-weight biomolecules such as lipids, sugars, amino acids, organic acids, and nucleotides

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Jessica           
Journal Manager
Panceratic Disorder and Therapy
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